Saturday، 22 February 2025

The thesis, presented by student Mai Rahim Abdul Hamza in the Department of Chemistry at the College of Science, discusses

"Assessing the Impact of Certain Factors and Their Relationship with Medications in the Serum of Thyroid Cancer Patients in Iraq."

Study Objective

The study aims to reveal the biomarkers associated with thyroid cancer, such as calcitonin, flavin-containing monooxygenases, and proto-oncogene tyrosine kinase, in addition to measuring the levels of certain vitamins like Vitamin C (VC), Vitamin D (VD), and Vitamin E (VE). The study also seeks to evaluate the differences in the levels of these biomarkers between thyroid cancer patients and healthy individuals, and to examine the changes in these levels before and after chemotherapy.

Study Summary
Thyroid cancer poses an increasing clinical challenge due to its diverse manifestations and rising incidence rates in recent decades. Although it accounts for only about 1% of all malignant tumors, understanding the biochemical indicators associated with it can aid in early diagnosis and improve therapeutic strategies.

The results showed that the levels of certain biomarkers change significantly among patients before and after chemotherapy. Among the most notable findings:
• The concentration of human flavin-containing monooxygenase (FMO1) was elevated in untreated patients compared to the control group and patients after treatment, indicating its potential use as a diagnostic marker.
• The analysis of the Receiver Operating Characteristic (ROC) curve for the FMO1 enzyme demonstrated a sensitivity of 100% and a specificity of 98% at a cutoff value of >227.5 nanograms/liter, with an AUC value of 1.0, indicating an ideal discriminatory ability between patients and the control group.
• The statistical values (p-value < 0.0001) confirmed the significance of these results, enhancing the potential of FMO1 as a biomarker for diagnosing thyroid cancer and monitoring treatment progress.